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Their methods sought to shortcut the sequencing of those portions of the human genome that are most relevant to drug discovery those portions encoding proteins by tagging expressed regions for focus in further research With the tag, or EST sequence, in hand, elucidation of the entire coding gene would be facilitated An SNP, or single-nucleotide polymorphism, is a mere single base pair variation from the reference genetic sequence found in most members of a population SNPs are the most common points of departure between the genomes of individuals, which are, for all apparent differences among people, virtually identical (Davies, 2001) SNPs located within the coding regions of genes themselves may have a direct effect on the protein production that is biologically benign, or profoundly negative, such as in causing disease (Davies, 2001).

Technical Report Groves C, Pantaleo M, Ericsson L, Anderson T and Taylor T 2003 Gateway control protocol, version 1 Technical Report RFC 3525, Internet Engineering Task Force (IETF) Gruber R, Kaashoek F, Liskov B and Shrira L 1994 Disconnected operation in the thor object-oriented database system IEEE Workshop on Mobile Computing Systems and Applications Guttman E, Perkins C, Veizades J and Day M 1999 Service Location Protocol, version 2 IETF, RFC 2608, http://wwwrfc-editororg/rfc/rfc2608 Guy RG, Heidemann JS, Mak W, Page TW, Popek JGJ and Rothmeir D 1990 Implementation of the ficus replicated file system Proceedings of the Summer 1990 USENIX Conference, 63 72 Gwon Y, Jain R and Kawahara T 2004 Robust indoor location estimation of stationary and mobile users IEEE INFOCOM, Hong Kong Hara S and Prasad R 1997 Overview of multicarrier CDMA IEEE Commun Mag 35(12), 126 133.

108 35

SNPs may thus give rise to disease, increased susceptibility to disease, sensitivity or insensitivity to certain drug treatments, or adverse side effects from those treatments Alternatively, SNPs may mark the presence of disease-causing genes or indicate disease susceptibilities or drug sensitivities Scrutiny of inheritance patterns of SNPs in families af icted with genetic disorders has revealed links to previously unknown disease genes in close proximity to SNPs within af icted individuals genomes (Davies, 2001) In this way, SNPs can demarcate errant disease genes, thereby facilitating the tracking and identi cation of the disease genes themselves The study of these small genetic differences is thus critically important in understanding disease and its treatment A full understanding of the SNPs of various disease subpopulations provides the potential for individualization of drug treatment on the basis of genetics.

Net_Profit_Margin Calculates and returns the Net Profit Margin (Income after Taxes / Total Revenue). NetProfit Cumulative dollar total of all closed-out trades, both winning and losing.

Risk management is the process of minimizing chances of project failure due to unplanned and undesirable circumstances. Since defects are both unplanned and undesirable, defect prevention is ultimately a risk mitigation technique.

The heated debate that has arisen over attempts to patent ESTs and SNPs stems from several main sources One argument against such patenting is that protection for ESTs and SNPs as research tools or probes provides exclusive use to materials critical in discovering and fully characterizing genes of interest and their corresponding proteins It is argued that these patents would prematurely grant exclusive means of access to full-length genes and, in effect, allow for clear pathways to eventual patenting of the whole genes for the fragment patent holder (Holman and Munzer, 2000; Rai, 2001) Thus,.

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Harkins D and Carrel D 1998a The Internet Key Exchange (IKE) Technical Report RFC 2409, IETF Harkins D and Carrel D 1998b The Internet Key Exchange (IKE) RFC 2409 Haverinen H and Salowey J 2003 EAP SIM Authentication draft-haverinen-pppext-eap-sim-12txt (work in progress) Henning M and Vinosky S 1999 Advanced CORBA Programming with C++ Addison-Wesley Herre J and Purnhagen H 2002 General audio coding In The MPEG-4 Book (eds Pereira F and Ebrahimi T), Prentice Hall Herzog J, Liskov M and Micali S 2003 Plaintext awareness via key registration Proceedings of Crypto 2003 Higuchi K, Andoh H, Okawa K, Sawahashi M and Adachi F 2000 Experimental evaluation of combined effect of coherent rake combing and SIR-based fast transmit power control for reverse link of DS-CDMA mobile radio IEEE J Selected Areas Commun 18(8), 1526 1535 Hinden R and Deering S 1995 IP Version 6 Addressing Architecture RFC 1884, IETF.

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case L : CCode5A::Lemniscate();break; case C : CCode5A::CreativeNet();break; } } void CCode5A::OnLButtonDown(UINT nFlags,CPoint pt) { if (rc1.PtInRect(pt)) { MenuChoice = P ; InvalidateRect(DrawRc); } if (rc2.PtInRect(pt)) { MenuChoice = L ; InvalidateRect(DrawRc); } if (rc3.PtInRect(pt)) { MenuChoice = C ; InvalidateRect(DrawRc); } if (!rc1.PtInRect(pt) && !rc2.PtInRect(pt) && !rc3.PtInRect(pt)) MenuChoice = X ; } void CCode5A::DrawAxes() { CClientDC dc(this); CPen penGray(PS_SOLID,2,Color2); dc.SelectObject(&penGray); dc.MoveTo(Origin.x,TopLeft.y+10); dc.LineTo(Origin.x,BottomRight.y-10); dc.MoveTo(TopLeft.x+10,Origin.y); dc.LineTo(BottomRight.x-10,Origin.y); } void CCode5A::Polynomial() { CClientDC dc(this); double X,Y; CPoint pt; DrawAxes(); // draw the curve, where X is magnified 50 times, Y 20 times X=-2; while (X<=4) { Y=X*(X+1)*(X-1)*(X-3); pt.x=(int)(50*X);